Stories tagged Cells


Sniffing Out Cancer: Amherst chemists develop a way to "smell" cancer cells.
Sniffing Out Cancer: Amherst chemists develop a way to "smell" cancer cells.Courtesy Jeremie63
Chemists from the University of Massachusetts Amherst have developed a way to quickly and accurately detect and identify metastatic cancer cells in living tissue, in much the same way that your nose can detect and identify certain odors.

The smell of a rose, for example, is a unique pattern of molecules, which activates a certain set of receptors in your nose. When these specific receptors are triggered, your brain immediately recognizes it as a rose.

Similarly, each type of cancer has a unique pattern to the proteins that make up its cells. The Amherst chemists just needed a "nose" to recognize these patterns. What they came up with was an array of gold nanoparticle sensors, coupled with green fluorescent proteins (GFP). The researchers took healthy tissue and tumor samples from mice, and trained the nanoparticle-GFP sensors to recognize the bad cells, and for the GFP to fluoresce in the presence of metastatic tissues.

This method is really sensitive to subtle differences, it's quick (can detect cancer cells within minutes), it can differentiate between types of cancers, and is minimally invasive. The researchers haven't tested this method on human tissue samples yet, but it holds some exciting potential.


The man behind the video: Drew Berry is a biomedical animator who is responsible for the fascinating scenes in Bjork's music video.
The man behind the video: Drew Berry is a biomedical animator who is responsible for the fascinating scenes in Bjork's music video.Courtesy John D. & Catherine T. MacArther Foundation
In the same vein as this Buzz post, here is another interesting blend of art and science. Bjork teams up with a biomedical animator to create a music video for her song "Hollow."

The animation is a mesmerizing, slightly creepy exercise of scale: it takes you down to the nanoscale, where you watch DNA replicate, then all the way back out to the macroscale, when you zoom out of Bjork's forehead. Interesting, indeed.


Zombies are not real right now because it is impossible. Well, until a scientist screws up. In the movies zombies are people that get infected from a source, it is unlikely that it will happen in our lifetime, but scientifically it will be brains( how ironic ), not bronze that prevails over this threat of zombies. The virus would most likely be like the T virus in Resident Evil, but we probably will never know. What do you think??? I was reading a article from the CDC and they say that it might be possible for a zombie apocalypse to happen! How do you think you would prepare for this??? Well we don't know. We honestly don't. Scientifically we would never truly be ready. And for an Awnser I don't want, "my dad has a gun"!!! Actual science reasons here. Heck, it might be a parasite for all we know, then again, your mom or dad may get it first( that would suck! ), or your sister, or brother. We will never know until we realize that nothing is impossible in science. Scientifically I should say, ELECTRICITY would go down first! Then GAS would eventually run out. Cities would be safe most of the time, because all the people would go out to the country.

Then all the people left would be in shock, and/or, injured and extremely prejudiced, but some will still be sane, like me, I know how to keep alive in a Z.A. but some people would not, but, scientifically someone will be smart and start remaking our civilization, but who knows maybe we will all die? You never know how things will turn out. What are your comments??? I would love to hear them.
EDITED BY LIZA, 11/1/2011: Hey, Buzzketeers! Still need a post-Halloween zombie fix, like ZombieDestroyer here? Head on over to the zombies page. You'll find out about a new zombie-fighting weapon, a real-life zombie-making parasite, and a very long-running thread about whether or not a zombie apocalypse is possible. (And if you feel a need to argue zombie-fighting strategies or likelihood, take it over to that last thread and keep it science-y, y'all!)


R/V Hespérides, docked at Aloha Tower in Honolulu, Hawai`i
R/V Hespérides, docked at Aloha Tower in Honolulu, Hawai`iCourtesy C-MORE
How would you like to be aboard a ship, circumnavigating the globe, collecting samples from the world’s ocean?

That’s exactly what Spanish oceanographers are doing on their Malaspina Expedition aboard the Research Vessel, R/V Hespérides. Scientists and crew left southern Spain in December, reached New Zealand in mid-April, and recently arrived in Hawai`i. The expedition's primary goals are to:

  • build upon the historic 1789-1794 Malaspina expedition to promote interest in marine sciences among the Spanish public, particularly the nation’s youth
  • collect oceanographic and atmospheric data -- chemical, physical and biological – that will help evaluate the impact of global change
  • explore the variety of marine life, including microbes, especially those living in the deep sea
  • CTD: As this oceanographic instrument is lowered over the side of a ship, each gray Niskin “bottle” can be electronically triggered to collect a seawater sample from a different ocean depth.
    CTD: As this oceanographic instrument is lowered over the side of a ship, each gray Niskin “bottle” can be electronically triggered to collect a seawater sample from a different ocean depth.Courtesy C-MORE
    In connection with the latter two goals, the Malaspina scientists met with their colleagues at the Center for Microbial Oceanography: Research and Education (C-MORE). The two groups of scientists are working together. "We can exchange data on the local effects, what's happening around the Hawaiian Islands, and they can tell us what's happening in the middle of the Pacific," said Dr. Dave Karl, University of Hawai`i oceanography professor and Director of C-MORE.

    The Malaspina-C-MORE partnership is the kind of cooperation that can help solve environmental problems which stretch beyond an individual nation’s borders. The R/V Hespérides has now left Honolulu on its way to Panama and Colombia. From there, the scientists expect to complete their ocean sampling through the Atlantic Ocean and return to Spain by July. Buen viaje!


the ocean's 5 major gyres
the ocean's 5 major gyresCourtesy NOAA
We often talk about the ocean ecosystem. And, indeed, there is really just one, world-wide ocean, since all oceans are connected. An Indian Ocean earthquake sends tsunami waves to distant coasts. Whitecaps look as white anywhere in the world. The ocean swirls in similar patterns.

However, oceanographers do find differences from place to place. For example, let’s take a closer look at the chemistry of two swirls, or gyres as they’re more properly called. Scientists have found a micro difference between the North Atlantic Gyre and the North Pacific Gyre. The Atlantic generally has really low levels of phosphorus, measurably lower than the North Pacific Gyre.

the element phosphorus among its neighbors in the Periodic Table of the Elements
the element phosphorus among its neighbors in the Periodic Table of the ElementsCourtesy modified from Wikipedia
Phosphorus is a very important element in living things. For example, it’s a necessary ingredient in ATP (adenosine tri-phosphate), the energy molecule used by all forms of life. Phosphorus is picked up from seawater by bacteria. All other marine life depends upon these bacteria, either directly or indirectly, for P. Therefore, if you’re bacteria living in the impoverished North Atlantic Gyre, you’d better be really good at getting phosphorus.

And they are!

Oceanographers at the Center for Microbial Oceanography: Research and Education (C-MORE) at the University of Hawai`i have made an important discovery. C-MORE scientists Sallie Chisholm, based at the Massachusetts Institute of Technology and her former graduate student Maureen Coleman, now a scientist at the California Institute of Technology, have been studying two species of oceanic bacteria. Prochlorococcus is an autotrophic bacterium that photosynthesizes its own food; Pelagibacter, is a heterotrophic bacterium that consumes food molecules made by others.

Pacific HOT and Atlantic BATS Stations: Microbial samples were collected at each location.
Pacific HOT and Atlantic BATS Stations: Microbial samples were collected at each location.Courtesy C-MORE
Drs. Chisholm and Coleman took samples of these two kinds of bacteria from both the Atlantic and Pacific Ocean. The Atlantic samples were collected by the Bermuda Atlantic Time-Series (BATS) program. The Pacific samples were collected in the North Pacific Gyre (about 90 miles north of Honolulu) by the Hawai`i Ocean Time-Series (HOT) program. The scientists discovered surprising differences in the genetic code of the bacteria between the two locations:

  • First of all, the Atlantic populations of both bacterial species have more phosphorus-related genes compared to their Pacific cousins. (Picture Atlantic microbes in Superman outfits with a big "P" on their chests!)
  • Secondly, in the Atlantic, Prochlorococcus has different kinds of P-related genes compared to Pelagibacter. Perhaps this means the two microbial species have evolved over time to use different phosphorus sources, to avoid competing with one another for this limited resource.

Drs. Chisholm and Coleman have discovered important micro differences between bacteria of the same species in two oceanic gyres. Now we can better understand how these microbes are working to recycle an important nutrient beneath the whitecaps.

Reference: October 11, 2010 issue of the Proceedings of the National Academy of Sciences


Earth, our place in space
Earth, our place in spaceCourtesy NASA
Life scientists study…well, life. They want to know everything about living things on planet Earth. One of the first things biologists want to know is who’s here. What kinds of plants and animals live in a forest? --or in a field? –or in the ocean?

If you’re an oceanographer who studies marine mammals, perhaps you’d go to sea on a ship with a good pair of binoculars and hunt for whales. As you focused your binoculars you’d be able to see different kinds of whale species. As you looked closer, for example at Humpback Whales, you'd see that each individual whale has a different black-white pattern on its tail. You might even take a biopsy, a small sample of whale flesh, and do a more detailed study of genetic differences among individual Humpbacks.

But what if you’re a microbial oceanographer? You sure can't use binocs to hunt for microbes! How can you study individual differences among tiny creatures that are only one-one-hundredth the width of a human hair? How do you hunt and capture single-celled bacteria, like Prochlorococcus, the most common bacterial species in the world’s ocean?

Invent something!

laser-based micro-fluidic system
laser-based micro-fluidic systemCourtesy C-MORE
Young scientists, Sebastien Rodrigue and Rex Malmstrom, at the Center for Microbial Oceanography: Research and Education (C-MORE) were doing research in Dr. Sallie Chisholm’s C-MORE lab at the Massachusetts Institute of Technology when they adapted a “laser-based micro-fluidic system” used commonly by medical researchers, for the study of marine bacteria. With this method they could put each individual tiny Prochlorococcus cell into its own little pool of seawater.

And then the excitement began.

ProchlorococcusCourtesy Dr. Anne Thompson, MIT
Even in scanning microscope photographs, each Prochlorococcus looks like just another teeny, tiny balloon; we can't see any individual differences. However, Sebastien and Rex used fast and inexpensive genetic methods and discovered an extraordinary variety of individual differences among Prochlorococcus. Of course the variety among these microbes doesn't have to do with tail patterns, like whales. Prochlorococcus vary in their method of getting nutrients, like iron, out of seawater.

So what? Why do we care?

We care A LOT because microbes like Prochlorococcus are operating at the nitty gritty level of cycling not only iron, but also other elements in the ocean. Like carbon. That's right, as in carbon dioxide accumulating in our atmosphere -- and ocean -- causing climate change and associated problems. The more we understand about individual differences among oceanic microbes, the more we'll understand how they influence and respond to changes in Earth's climate.


You probably know that plants "inhale" carbon dioxide and "exhale" oxygen, but did you know that plants also release water into the air when they exhale? This process is called transpiration, and it plays an important part in our planet's water cycle. I mean, just think of all the billions of plants out there, all of them transpiring 24/7--that really adds up.

Unfortunately, increasing carbon dioxide in the atmosphere has yet another impact on our ecosystems--it reduces transpiration. You see, plants have these tiny pores on the undersides of their leaves called stomata. The stomata open and close depending on the amount of carbon dioxide available in the air and how much they need of it.

It's kind of like your eye's iris--your eye needs an ideal amount of light to see, so when it's bright outside, the iris closes in. This shrinks the pupil so that it only takes in a small amount of light. In lower light, the iris opens, making the pupil larger so that it takes in more light. Like your iris, the stomata open and close to let in the right amount of carbon dioxide.

Stomata: These stomata are from an Arabidopsis plant. The top one is open, and the lower one is closed.
Stomata: These stomata are from an Arabidopsis plant. The top one is open, and the lower one is closed.Courtesy KuriPop

Unfortunately, a recent study showed that with carbon dioxide concentrations increasing quickly, plant stomata are closed longer than they were 150 years ago. There are also simply fewer stomata in leaves. While this controls the amount of carbon dioxide they're absorbing, it has the added outcome of limiting the amount of water released into the air from plants. Over time, this could add up to some significant change--but it's a little early to tell for sure what the impacts will be.

It's kind of amazing to see how changes in carbon dioxide emissions have such far-reaching impacts beyond the one we hear about every day--global warming. Luckily, we have plenty of ways to work on global warming and curtail carbon dioxide emissions, such as cement that absorbs carbon dioxide as it hardens, castles that scrub CO2 from the air, and solar power concentrators that generate 1500 times as much energy as regular solar cells, reducing our dependence on fossil fuels.

What's your favorite way to ditch carbon dioxide?


We've written about freaky frogs on the Buzz Blog before, but some recent news may shed new light on our abnormal amphibians. Until recently, researchers thought that atrazine, an agricultural pesticide, was the sole cause of sexual deformities in frogs. Unfortunately, it's not so simple.
UT OH: What lurks in me waters?
UT OH: What lurks in me waters?Courtesy Mike Ostrowski

An ecologist at Yale University, David Skelly, sought to test assumptions about atrazine by studying the frequencies of frog deformity in different land types--agricultural, suburban, urban, and forested. Skelly expected to find the highest rates of deformities in agricultural areas, which would be consistent with atrazine being the main cause. Curiously, he found the highest rates of deformity in urban and suburban areas--places we wouldn't expect to find much atrazine. So what's going on?

It turns out that what makes atrazine so dangerous is that it mimics estrogen and binds to estrogen receptors in frog cells. Because estrogen impacts sexual development and function, so too does atrazine. But atrazine isn't the only estrogen-mimicking compound out there--there's a whole class of chemicals that mimic estrogens, including those found in birth control pills and plastics (BPA). And these chemicals are found in droves in cities and surburban areas--they're flushed into the sewage, but aren't filtered out during water treatment.
Birth control pills: Estradiol, a synthetic estrogen, helps prevent pregnancy in women. But much of it is excreted in urine and eventually makes its way into various water sources.
Birth control pills: Estradiol, a synthetic estrogen, helps prevent pregnancy in women. But much of it is excreted in urine and eventually makes its way into various water sources.Courtesy Ceridwen

So why do we care? Besides the fact that frogs are just awesome little creatures and important parts of their food webs, they have something in common with humans--estrogen receptors. The same chemicals that impact frogs can impact us. So how do we humans keep our sexual development and functioning intact?
BPA-free: This Sigg bottle is made from enameled aluminum, and it's an example of a BPA-free bottle.
BPA-free: This Sigg bottle is made from enameled aluminum, and it's an example of a BPA-free bottle.Courtesy Bucklesman

Skelly had a great idea to filter this stuff out of the water at the treatment plant, so that it won't get into our bodies from drinking water. He also suggested that regulatory changes would help so that when new chemicals are developed, they're scrutinized for unintended side effects. And of course, we can make choices that reduce our exposure, such as by buying BPA-free plastics, or using stainless steel and glass containers. And of course, increased awareness is always a good idea.

Do you take extra steps to avoid things like BPA? What are they?


ocean micro-plastic: These samples were collected from the surface water of the North Pacific Ocean by the SUPER expedition in 2008.
ocean micro-plastic: These samples were collected from the surface water of the North Pacific Ocean by the SUPER expedition in 2008.Courtesy C-MORE
Who hasn’t heard that plastic in the ocean is trouble?

  • Plastic has been found clogging the stomachs of dead albatross and other ocean birds.
  • Plastic ropes and traps have entangled marine life, causing more death.
  • As a long-lasting chemical, plastic floating in the ocean provides long-distance rafts that may move aggressive alien marine life to new areas.
  • Plastic may provide a “sticky” surface where toxins can accumulate, becoming a concentrated source of poison for marine consumers.
  • A "Great Pacific Garbage Patch" has been reported to be an "island the size of Texas" floating in the North Pacific Ocean...but is this really true? Continue reading to find out!

Yep, plastic in the ocean is bad news; so let’s put scientific energy into studying and solving the problem.

manta trawl: The trawl is hoisted above the stern deck of the RV Kilo Moana.
manta trawl: The trawl is hoisted above the stern deck of the RV Kilo Moana.Courtesy C-MORE
In 2008 C-MORE, the Center for Microbial Oceanography: Research & Education headquartered at the University of Hawai`i, with assistance from the Algalita Marine Research Foundation, embarked on an oceanographic expedition aboard the RV Kilo Moana, which means "oceanographer" in Hawaiian. The goal of the expedition, dubbed SUPER (Survey of Underwater Plastic and Ecosystem Response Cruise), was to measure the amount of micro-plastic in the ocean. In addition, oceanographers took samples to study microbes and seawater chemistry associated with the ocean plastic. The Kilo Moana sailed right through the area known as the “Great Pacific Garbage Patch,” between Hawai`i and California.

Early results: there was no garbage patch/island. Once in a while something like a barnacle-covered plastic buoy would float past the ship, but mostly the ocean looked really clean and empty of any kind of marine debris.

manta trawl: The net is being pulled slowly through the ocean's surface water.
manta trawl: The net is being pulled slowly through the ocean's surface water.Courtesy C-MORE
But wait! Scientists looked closer and were amazed. Every single one of the more than a dozen manta trawls, filtering the surface seawater for an hour and a half each, brought up pieces of micro-plastic! Some were as small as 0.2 millimeter, mixed among zooplankton!

Other expeditions have reported similar results (for example, Scripps Institution of Oceanography's 2009 SEAPLEX expedition and Sea Education Association's North Atlantic Expedition 2010): no Texas-size garbage patches, but plenty of plastic marine debris to worry about. The data seem to show that most of the plastic is in the form of small pieces spread throughout upper levels of water at some locations around the world's ocean. In these areas, the ocean is like a dilute soup of plastic.

Dr. White: examining the results of a manta tow
Dr. White: examining the results of a manta towCourtesy C-MORE
C-MORE researcher Dr. Angelicque (Angel) White, assistant professor of oceanography at Oregon State University (OSU) was a scientist on board the SUPER expedition. In recent interviews, (for example: the Corvallis Gazette-Times and Dr. White cautions us to view the complex plastic marine debris problem accurately. Furthermore, new results will soon be published by C-MORE about microbial diversity and activity on plastic pieces.

In the meantime, as Dr. White says, “…let’s keep working on eliminating plastics from the ocean so one day we can say the worst it ever became was a dilute soup, not islands. “

Plastic in the ocean is trouble. How can you be part of the solution?


This Wednesday evening kicks off a super-exciting four-part NOVA series about nanotechnology called Making Stuff. Each episode focuses on one general concept: stronger, smaller, cleaner, smarter. We could just squeal.

Spider Web +
Spider Web +Courtesy National Science Foundation

I was honored to get a sneak-preview of the first episode, Making Stuff: Stronger in San Francisco in October, and found myself in some crazy conversations afterward about bioengineering and media ethics. You see, scientists have, uh, installed spider silk-making genes into goats, thereby making the goat milk spinnable into spider silk. The Making Stuff episode covers this, then ends by showing the host happily drinking a glass of milk, and we’re left wondering if it's actually the spider-silk-milk that he’s downing without a care in the world.

Baby Goat =
Baby Goat =Courtesy National Science Foundation

2020 Science, the blog of Andrew Maynard, scientist, science policy guru, and Director of the Risk Science Center at the University of Michigan School of Public Health, kindly takes the conversation beyond “ew!” to “responsible?” Andrew was also in the room for the special preview, and raised far more eloquent concerns than I (I’m sorry – I’m still stuck on the spiders…ew), and then blogged about them. And then got substantive responses, including one from Making Stuff’s producer, Chris Schmidt. All a fascinating read.

Andrew, being the smart, informed fellow that he is, pointed out that this whole spidergoat concept is old news. Bioengineered Spider Silk
Bioengineered Spider SilkCourtesy National Science Foundation
No less icky and/or creepy I would add, but still old news. Can’t wait until the Making Stuff episode that delves into the topic on Wednesday? Take a peek at the short video put together by the National Science Foundation.