May
31
2009

How to make a swine flu vaccine

Vaccine production
Vaccine productionCourtesy AJC1

US pays billion dollars for developing new flu vaccine

The latest information from Pandemicflu.gov explains the next steps toward an H1N1 influenza vaccine.

BARDA

The Biomedical Advanced Research and Development Authority (BARDA), which is part of the Dept. on HHS, has an official "fact sheet" explaining 2009 H1N1 Vaccine Development Activities.

U.S. Department of Health & Human Services (HHS) Secretary Kathleen Sebelius is directing nearly $1.1 billion in existing preparedness funds to manufacture two important parts of a vaccine for the Strategic National Stockpile, to produce small amounts of potential vaccine for research, and to perform clinical research over the summer. HHS press release

How do vaccines work?

Vaccines work by tricking the immune system into thinking it has been infected with the H1N1 swine flu virus so that it creates antibodies against it. The vaccine is a hybrid of the virus which is similar enough that our immune system will develop antibodies against a specific virus.

How is swine flu vaccine made?

We are now starting step 4.

  1. obtain typical sample of novel H1N1 virus
  2. reproduce sample in eggs
  3. Mix H1N1 and PR8 viruses into eggs and allowing a hybrid strain to be created through a natural re-assortment of their genes
  4. Multiply seed virus into millions of doses
  5. test virus in people to determine the most effective and safest dose to generate a strong immune response to the 2009-H1N1 virus
  6. decide whether to use adjuvants
  7. mass produce vaccine

What is an adjuvant?

An adjuvant is an additive to a vaccine that helps to generate a stronger immune response to the vaccine. When using an adjuvant it is often possible to reduce the size of the vaccine dose and the number of doses needed. Special permission from the Food and Drug Administration will be needed for the adjuvants to be used, as neither one is currently approved for use in this country. Washington Post

Can vaccines be made without using eggs?

"The federal government has given the vaccine industry $1.3 billion to spur a shift from growing the viruses in eggs to growing them in stainless steel tanks containing mammalian cells.

Such cell culture could shave a few weeks off the process, experts estimate, and would eliminate the need for millions of eggs on short notice. Some vaccines made in cells have been approved in Europe but not in the United States." New York Times

Learn more about making swine flu vaccine

How to make a swine flu vaccine BBC
CDC May 28 Press Briefing transcript
Flu vaccine development questions and answers BARDA

Your Comments, Thoughts, Questions, Ideas

Anonymous's picture
Anonymous says:

Hay!

posted on Mon, 06/01/2009 - 12:25pm
Anonymous's picture
Anonymous says:

if there is a cure why are people diying

posted on Fri, 06/19/2009 - 7:01pm
Anonymous's picture
Anonymous says:

Because a vaccine is not a cure. It is a preventative measure.

posted on Wed, 06/24/2009 - 2:35pm
stephanie  cok's picture
stephanie cok says:

hay! How do you not get sick?

posted on Thu, 07/09/2009 - 12:11pm
Anonymous's picture
Anonymous says:

there is no vaccine yet

posted on Mon, 07/13/2009 - 4:02pm
alyssa's picture
alyssa says:

i thought that the h1n1 flu virus was cominmg from mexico but it wasnt .(:

posted on Sat, 07/25/2009 - 1:50pm
Kati's picture
Kati says:

mee and my friends call the H1N1 flu virius the R2D2 desese :) hahahahahahahaha even tho its a very serious flu :)

posted on Sat, 07/25/2009 - 1:52pm

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